All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional.

The GvHD Hub uses cookies on this website. They help us give you the best online experience. By continuing to use our website without changing your cookie settings, you agree to our use of cookies in accordance with our updated Cookie Policy

Introducing

Now you can personalise
your GvHD Hub experience!

Bookmark content to read later

Select your specific areas of interest

View content recommended for you

Find out more
  TRANSLATE

The GvHD Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the GvHD Hub cannot guarantee the accuracy of translated content. The GvHD Hub and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.

Steering CommitteeAbout UsNewsletterContact
LOADING
You're logged in! Click here any time to manage your account or log out.
LOADING
You're logged in! Click here any time to manage your account or log out.
2018-09-11T14:52:37.000Z

Checkpoint inhibitors administered before and after allo-HSCT may increase the risk of graft-versus-host disease

Sep 11, 2018
Share:

Bookmark this article

Awais Ijaz from the University of Arizona, Tucson, AZ, USA, and colleagues retrospectively evaluated the safety, efficacy and risks of checkpoint inhibitors (CPIs) in patients with hematological malignancies undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). CPIs can enhance graft versus tumor (GVT) effect, whereas the risk of graft-versus-host disease (GvHD) may increase. The study was published in Biology of Blood and Marrow Transplantation.

Twenty-four articles (13 case reports and 11 original manuscripts) were selected from PubMed regarding CPIs administered for patients with hematological malignancies either before or after allo-HSCT.

Study overview

  • N = 283 patients
  • Original articles
    • CPI was administered before allo-HSCT in 107 patients
      • N = 91 patients received nivolumab
      • N = 11 patients received pembrolizumab
      • N = 8 patients received ipilimumab
    • CPI was administered after allo-HSCT in 150 patients
      • N = 62 patients received nivolumab
      • N = 85 patients received ipilimumab
      • N = 4 patients received pembrolizumab
    • Case reports
      • CPI was administered after allo-HSCT in 26 patients
        • N = 14 patients received nivolumab
        • N = 12 patients received pembrolizumab

Key findings

Data from original articles

  • Safety and efficacy when CPI was given prior to allo-HSCT
    • GvHD
      • Hyper-acute GvHD: 8 patients (7%)
      • Acute GvHD: 60 patients (56%)
      • Chronic GvHD: 20 patients (29%)
    • Overall response rate (ORR) in 62 evaluable patients: 68% (42/62)
      • Complete response (CR): 47% (29/62)
      • Partial response (PR): 21% (13/62)
    • Stable disease (SD): 11% (7/62)
    • Progressive disease (PD): 19% (12/62)
    • Twenty patients died, 12 deaths occurred due to GvHD
  • Safety and efficacy when CPI was given after allo-HSCT
    • GvHD
      • Acute GvHD: 19 patients (13%)
      • Chronic GvHD: 7 patients (11%)
    • ORR: 59 patients (48%)
      • CR: 34 patients (28%)
      • PR: 25 patients (20%)
    • SD: 7 patients (6 %)
    • PD: 4 patients (3%)
    • Thirty-five patients died, 10 deaths were GvHD related

Data from case reports

  • Safety and efficacy when CPI was given after allo-HSCT
    • CR: 15 patients (58%)
    • PR: 7 patients (30%)
    • SD: 1 patient (4%)
    • PD: 1 patient (4%)
    • GvHD
      • Acute GvHD: 5 patients (19%)
      • One patient (4%) had an exacerbation of existing GvHD
    • 15% of patients died, one of them due to GvHD

The authors concluded that the rate of acute GvHD was high (56%) in patients who received CPI therapy prior to allo-HSCT. They added that “this rate is higher than the historical incidence that ranges between 26% to 50%.” In addition, CPIs received after allo-HSCT led to superior efficacy, but also increased the risk of GvHD (14% acute, 9% chronic). The study group further stated that “there is need for extreme caution while making decisions regarding the use of CPI.” Further prospective clinical trials are required to confirm these findings.

  1. Ijaz A. et al. Significant Risk of Graft-versus-Host Disease with Exposure to Checkpoint Inhibitors Before and After Allogeneic transplantation. Biol Blood Marrow Transplant. 2018 Sep 5. DOI: 1016/j.bbmt.2018.08.028. [Epub ahead of print].

Newsletter

Subscribe to get the best content related to GvHD delivered to your inbox